Complement mediates early synapse loss in mouse models of Alzheimer’s disease

Our lab has published a study indicating that the classical complement cascade promotes early synapse loss in mouse models of Alzheimer’s disease. Congratulations to Soyon Hong and everyone else in the lab who participated in this exciting work!

You can learn more about the study at Science, Scientific American, or  STAT News. 

Complement link to schizophrenia

Our lab has co-authored a study together with the McCarroll and Carroll labs (at HMS and BCH, respectively) suggesting a link between schizophrenia, complement, and aberrant synaptic pruning. Congratulations to everyone who contributed to this work!

See the New York Times, NPR, and the MIT Technology Review for more information about the study and its implications for human health.

Beth Stevens named 2015 MacArthur Fellow

Beth Stevens, Assistant Professor of Neurology at Children's Hospital in Boston, Massachusetts, Friday, September 18, 2015. (John D. and Catherine T. MacArthur Foundation)

Beth Stevens, Assistant Professor of Neurology at Children’s Hospital in Boston, Massachusetts, Friday, September 18, 2015. (John D. and Catherine T. MacArthur Foundation)  CC – BY

We’re proud to announce that Beth is a 2015 MacArthur fellow! According to the MacArthur Foundation website, these fellowships are awarded to “talented individuals who have shown extraordinary originality and dedication in their creative pursuits and a marked capacity for self-direction. There are three criteria for selection of Fellows: exceptional creativity, promise for important future advances based on a track record of significant accomplishment, and potential for the fellowship to facilitate subsequent creative work”. Congratulations Beth!

See the MacArthur Foundation’s summary of Beth’s work here.

Read about the other 2015 fellows here.

Dori Schafer starts her lab at UMass Medical School

Dori Schafer, founding member of the Stevens lab, has moved to UMass Medical School to start her own lab. There she will be continuing the work on the roles of neuron-glia interactions in synaptic development and plasticity that she pioneered while in the Stevens lab. We will miss her, but wish her the best of luck for the future! Here is more information about her lab at UMass: http://profiles.umassmed.edu/Profiles/display/11500747