Complement mediates early synapse loss in mouse models of Alzheimer’s disease

Our lab has published a study indicating that the classical complement cascade promotes early synapse loss in mouse models of Alzheimer’s disease. Congratulations to Soyon Hong and everyone else in the lab who participated in this exciting work!

You can learn more about the study at Science, Scientific American, or  STAT News. 

Complement link to schizophrenia

Our lab has co-authored a study together with the McCarroll and Carroll labs (at HMS and BCH, respectively) suggesting a link between schizophrenia, complement, and aberrant synaptic pruning. Congratulations to everyone who contributed to this work!

See the New York Times, NPR, and the MIT Technology Review for more information about the study and its implications for human health.